Step 2 - Pharmacy 2013

It is required to prove the presence of bismuth ions in the mineral residue. What preliminary reaction is used for this purpose?

With copper acetate

With sodium rhodizonate

With potassium chromate

With 8-hydroxyquinoline

With dithizone

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A pharmacy prepared a solution of macromolecular substance with limited swelling capacity. What solution was labelled 'warm up before use'?

Pancreatin

Pepsin

Trypsin

Gelatin

Methyl cellulose

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A pharmacy rceived a prescription for ethyl alcohol. What amount of alcohol can be dispensed to the patient with diabetes free of charge?

50 g per month

200 g per month

100 g per month

There is no standard

150 g per month

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Schedule of sanitation actions in pharmacies is regulated by the relevant regulatory acts. Cleaning day at a pharmacy must be scheduled for at least 1 time:

In 10 days

In a week

In 5 days

In a month

In 3 days

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6 months after treatment a patient with coronary heart disease developed tolerance to the prolonged-action nitrates. What drug with nitrate-similar effect should be recommended in this case?

Nifedipine

Metoprolol

Molsidomine

Prazosin

Verapamil

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Losartan for treatment of arterial hypertension is contraindicated in case of:

Hyperlipidemia

Pregnancy

Urine acid diathesis

Hypokalemia

Hyperglycemia

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A patient with hypertensive crisis has been given an intravenous injection of clonidine. What mechanism underlies the antihypertensive effect of clonidine?

Blockade of peripheral a-adrenergic receptors

Direct myotropic effect on blood vessels

Blockade of в-adrenergic receptors

Blockade of N-cholinergic receptors

Stimulation of the central presynaptic a2-adrenergic receptors

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A patient with the symptoms of cardiac glycoside intoxication has been administered unitiol. What is the mechanism of therapeutic action of this drug?

Increased penetration of K + into the cardiac myocytes

Binding of the ionized Ca2+

Increase in Na+ level in the myocardium

Reactivation of the membrane K +, Na+-ATPase

Induction of cardiac glycosides metabolism

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A 38-year-old male patient with mercuric chloride intoxication has been delivered to the admission ward in grave condition. What antidote must be immediately administered the patient?

Nalorphine

Unithiol

Izonitrozinum

Atropine

Dipyroxime

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Standard herbal material of lily-of-the-valley is obtained by drying it at a temperature of 50-60 oC in order to prevent the following possible biochemical process :

Oxidation of terpenoids

Enzymatic hydrolysis of cardiac glycosides

Oxidation of resins

Volatilization of essential oils

Oxidation of phenolic compounds

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Which drug including the beta-lactam cycle in its structure gives a positive reaction with a solution of hydroxylamine hydrochloride in the presence of sodium hydroxide followed by adding the solution of iron (III) chloride?

Phenoxymethylpenicillin

Papaverine hydrochloride

Antipyrine

Dibazolum

Streptocid

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A pharmaceutical plant produces spi-ssum extract with 0,25% ammonia solution used as an extractant. This is a spissum extract of:

Valerian

Motherwort

Male fern

Licorice

Sagebrush

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A person got poisoned with the lead compounds. What is the most sensitive method of the quantitative analysis of lead ions?

Photometry

Chelatometry

Atomic absorption spectrometry

Dichromate iodimetry

Gravimetry

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A marketing manager of a pharmaceutical company carries out market research on vitamin preparation market. He takes into account various parameters including the therapeutical effectiveness, supply and demand. What method should be applied?

Mathematical statistics method

Method of extraction from the original medical records

Graph method

-

Delphi method

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A factrory workshop producing suspensions and emulsions is going to develop the manufacture of new drugs. What mechanisms can be used for the ultrasound processing of drugs?

Rotor-pulsation apparatus, di-smembrator

Centrifugal mixer with rotating housing

Liquid whistle, magnetostrictive source

Dismembrator, electrical impulse plasmolyzer

Disintegrator, liquid whistle

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A pharmaceutist prepared a lipophilic ointment of suspension type. What substance is used for preparing this kind of ointments?

Herbal extracts

Menthol

Xeroform

Protargolum

Tannin

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A pharmaceutist has a labour dispute with the pharmacy administration about rescheduling his annual vacation leave. The employee can appeal against the decision of the pharmacy administration to the following body:

MoH of Ukraine

Labour disputes commission (LDC)

Trade union committee

Commercial court

Highest management bodies of pharmaceutical service at the regional level

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Medications Passit and Novopassit are used as tranquilizing, sedative and mild hypnotic agents. These medications are produced from the following grass:

Purple passionflower

Three-lobe beggarticks

Elecampane

Lesser periwinkle

Garden sage

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During transportation, the markings on the packages of theobromine and theophylline were damaged. What solution allows to identify theobromine and theophylline?

Potassium dichromate

Cobalt chloride

Copper nitrate

Sodium chloride

Potassium permanganate

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Which of the following antihypertensive drugs has potassium-sparing action?

Triamterene

Diltiazem

Metoprolol

Furosemide

Prazosin

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What drug acts as a specific antidote in case of iron drug intoxication?

Protamine sulfate

Atropine

Penicillamine

Deferoxamine

Bemegride

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A regional medical representative of a foreign company uses the data derived from periodicals and reference and statistical materials in order to characterize the territorial pharmaceutical market. What kind of market research is based upon these sources?

Desk studies

All answers are correct

This method does not apply to research

Field studies

-

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A pharmaceutist was on a business trip. What is the deadline for submitting a travel expense report?

There is no deadline

Three working days after returning from a trip

A week after returning from a trip

Four working days after returning from a trip

Ten working days after returning from a trip

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An accountable person (accountant) has been given some cash from the cash account of the company for the purchase of stationery goods . What is the deadline for submitting a full statement of the accountable person on the cash use after receiving the cash?

Ten working days

There is no fixed term

Third banking day

Five working days

One week

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A pharmaceutist prepares trituration of atropine sulfate. What adjuvant should be used for this purpose?

Glucose

Lactose

Starch

Talc

Saccharose

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A pharmaceutical factory produces tablets of sodium chloride. What is the method of their poduction?

Direct compression with the addition of excipients

Moulding

Dry granulation prior to compression

Wet granulation prior to compression

Direct compression without additional substances

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A pharmaceutical factory produces suspensions and emulsions. Specify the equipment which is used for dispersion and mixing in the liquid medium:

Oscillating mixers

Rotor-pulsation apparatus, colloid mixers

Anchor mixers

Gate mixers

Drum mixers

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A pharmaceutist prepared eye drops containing silver nitrate. What substance must be taken to ensure isotonicity?

Sodium nitrate

Boric acid

Glucose

Sodium sulfate

Sodium chloride

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In order to detect the presence of thiosulfate ions a pharmaceutical analyst added the excess reagent. The resulting reaction produced a white precipitate, which slowly turned yellow, then brown, and black. What solution was added?

Ammonium oxalate

Barium chloride

Silver nitrate

Lead (II) acetate

Diphenylamine

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Collective labour agreement is concluded by a trade union committee with the enterprise owner on behalf of the workforce. Any collective agreement is worked out in written form. Which article of the Labor Code regulates the duration of the collective agreement?

36

40

17

41

38

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A person got poisoned with salts of manganese. Analysis of the mineral residue revealed manganese ions. What reactions underlie the chemical processes of manganese detection?

Hydrolysis

Neutralization

Dissociation

Oxidation-reduction

Metathesis

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A pharmaceutist prepares a solution for injections that must be stabilized with 0,1M of hydrochloric acid solution. What solution is to be prepared?

Sodium benzoate

Hexamethylenetetramine

Calcium chloride

Potassium chloride

Novocaine

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Paracetamol substance has been sent for analysis. Reaction with the solution of iron (III) chloride gave the blue-purple colour. This indicates the presence of:

Phenolic hydroxyl

Aldehyde group

Keto group

Ester group

Alcoholic hydroxyl

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Production of tablets requires stage-to-stage quality control. What devices are used to determine the particle size distribution (fraction) of granules?

Microscope

Standard set of sieves

Friabilators

Various vibrosieves

Laboratory IDs

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Analysis of the drug sales performance revealed market expansion, the absolute increase of the drug in manufacturer’s stocks, slowdown in the growth rate of sales, intense competition. What stage of the product life cycle is the drug in?

Growth

Maturity

Introduction

Development

Saturation and decline

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Anthracene derivatives of emodin have purgative effect. Large quantities of anthracenederived groups of emodin are contained in the fruits of the following plant:

Blueberry (Vaccinium myrtillus)

Alder buckthorn (Frangula alnus)

Blackcurrant

Buckthorn

Elder (Sambucus)

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Theory of management currently points out four the most important approaches to the management. Select the approach that is NOT applied in the theory of management:

Systemic

Situational

Structured

Different schools dedication approach

Process approach

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A pharmaceutist worked on a holiday, and the time worked was within the normal working hours of the current month. The employee would be entitled to be paid:

There would be no penalty rates

Fixed salary + one daily rate

According to the standard procedure as for a normal working day

Fixed salary + double daily rate

Single piecework rate

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A pharmacy has a license for selling narcotic drugs. The warrant for the receipt of these drugs from the pharmacy warehouse is valid for:

No longer than one calendar days from the date of issue

No longer than one year from the date of issue

No longer than three months from the date of issue

No longer than 10 calendar days from the date of issue

No longer than five calendar days from the date of issue

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Help the doctor to select a drug for the replacement therapy after the thyroid gland removal:

Prednisolone

Parathyroidin

L-thyroxine

Insulin

Mercazolilum

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Chloride of lime is identified by calcium cations after boiling with acetic acid in order to eliminate active chlorine. What reagent is used?

Potassium chloride

Magnesium sulfate

Ammonium molybdate

Ammonium oxalate

Sodium nitrite

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The medicine 'Bismuthi subnitras'can be identified after dissolving it in the acid with the following reagent:

Potassium iodide

Potassium chlorate

Sodium chloride

Sodium sulfate

Potassium nitrate

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Sterilization methods used for the preparation of drugs under aseptic conditions can be differentiated into physical, mechanical, and chemical ones. Specify the chemical method of sterilization:

UV light sterilization

Pressure steam sterilization

Radiation sterilization

Dry heat sterilization

Addition of preservatives

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Activity of a company leader involves managerial decision-making aimed at the achievement of corporate goals. Which of the following decisions are NOT classified by the method of justification?

Standard

Rational

-

Intuitive

Decisions based upon judgements

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Pharmacies prepare triturations of toxic and superpotent substances. They can be prepared in a following ratio:

1:1000

1:10 only

1:10 and 1:100

1:500

1:100 only

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It is required to prepare furacilin solution (1:5000). What is the dissolution peculiarity of furacilin?

It dissolves in the boiling water purified in the presence of sodium chloride

It dissolves in the purified water after the trituration

It dissolves in the filtered purified water

It dissolves in the cold purified water

It dissolves in a minimal amount of ethyl alcohol

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The method of suspension preparation depends on the properties of its components. Specify the substances having hydrophobic properties:

Sodium bicarbonate, sodium sulfate

Boric acid, calcium carbonate

White clay, bentonite

Zinc oxide, talc

Camphor, menthol

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A patient has been prescribed hand-rolled rectal suppositories with 0,1 g of aminophylline. What is the amount of base required for each suppository, provided that the suppository weight is not specified in the formulation?

1,9 g

1,4 g

2,4 g

2,9 g

3,9 g

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Pharmaceutical depot received a batch of herbal material of cinnamon rose. What substance determines the quality of the raw material?

Ascorbic acid

Anthracene derivatives

Tannins

Coumarins

Essential oil

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A pharmaceutist prepares an ointment on a hydrophobic base. What substance does he use in order to reduce the melting point of the base?

Dimexide

Ethanol

Vaseline oil

PEG-40

Glycerol

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In order to identify deoxycorticosterone acetate a pharmaceutical analyst performed a steroid cycle reaction, which resulted in formation of cherry-red colour and a green fluorescence. What reagent was added?

Iodine solution

Iron (III) chloride solution

Concentrated sulfuric acid

Chloroform

Potassium hydroxide solution

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An analytical laboratory received a sample of alpha-aminobutyric acid for analysis. What reagent should be used by the analyst in order to identify this substance?

Ninhydrin

Sodium nitrate

Aniline

Benzene

Calcium bromide

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A retail pharmacy has been purchasing goods within an accounting period. What changes to the balance will result from this business transaction?

Decrease in assets and liabilities

-

Increase in assets and liabilities

Changes will be caused to the assets only

Changes will be caused to the liabilities only

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Leaves of greater plantain are harvested in summer by mowing or cutting them with a knife or a sickle. There is always one developed plant left per 1 m2. The plant is harvested in the following vegetation period:

Ripeness

Rosetting

Blooming

Beginning of fruiting

Budding

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A manufacturing enterprise plans to sell a new drug through the corporate chain of pharmacies. What strategy of drug distribution would be used?

Multi-echelon

Direct

Flexible

Vertical integration

Horizontal integration

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The quality of tablets is assessed by various factors. What instrument is used for the tablet disintegration test?

Friabilator

-

Paddle

Flow-through device

Basket apparatus

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A pharmaceutical manufacturer develops a system of product. The focus is laid on the maximum involvement of agent network. What type of marketing is applied?

Exclusive

-

Combined

Intense

Selective

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While preparing marshmallow root extract, a pharmaceutist mistakenly used the water of improper temperature for this extract, and the end product came up turbid. What is the required water temperature for the extraction of this herbal material?

80 oC

40 oC

100 oC

60 oC

Room temperature

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A 67-year-old patient with chronic heart failure takes digoxin. In order to reduce its side effects the patient’s doctor recommended to combine it with the followig drug:

Hydrochlorthiazide

Euphyllinum

Calcium gluconate

Panangin

Calcium chloride

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A certain plant is used for production of tinctures and extracts which are the part of complex drugs Bellataminal, Becarbon, Besalol, etc. Specify the grass that is used for this purpose:

Beggarticks

Lily of the valley

Astragalus

Belladonna

Celandine

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A woman who has been treated for infiltrative focal tuberculosis for a long time complains of acute hearing impairment. Which of the following preparations might be the cause of this side effect?

Ethionamidum

Ethambutol

Isoniazid

Streptomycin

Rifampicin

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A pharmaceutist prepared a drug by the prescription: Rp.: Streptocidi Dermatoli ana 1,0 Lanolini Vaselini ana 5,0 M.D.S.: Apply to the affected skin. Specify the type of the disperse system:

Suspension ointment

Solution ointment

Hydrophilic ointment

Combined ointment

Extraction ointment

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Which of the following antibiotics can be identified by means of the maltol test?

Kanamycin monosulfate

Amoxicillin

Lincomycin hydrochloride

Streptomycin sulfate

Doxycycline hydrochloride

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Pharmacies as legal entities must have statutory capital in order to get registered with state authorities. Specify the amount which is identified as the statutory capital:

Total assets

Amount recorded in the constituent documents

Total sources of funds

Outstanding amount

Amount of noncurrent assets

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A pharmaceutist prepared 100,0 g of oil emulsion using 5% solution of methyl cellulose as an emulsifier. Specify the required amount of oil and emulsifier for the drug preparation:

10,0 g, 20,0 g

20,0 g, 30,0 g

10,0 g, 10,0 g

20,0 g,10,0g

10,0 g, 30,0 g

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A pharmaceutist prepared the 2% aqueous solution by dissolving the drug substance triturated in a mortar. What substance is this technology typical for?

Calcium gluconate

Potassium bromide

Osarsolum

Potassium permanganate

Boric acid

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A pharmaceutist prepares powders with papaverine hydrochloride. What hand scales should be used for weighing out 0,05 g of substance?

BP 20,0

BP 10,0

BP 5,0

BP 2,0

BP 1,0

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What drug can be recommended for symptomatic treatment of muscle pain in a 5-year-old child?

Acetylsalicylic acid

Celecoxib

Diclofenac sodium

Indomethacin

Paracetamol

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A pharmacy received a prescription for an oil liniment including streptocidum. What is the type of disperse system of this preparation?

Alloy

Suspension

Combined

Solution

Emulsion

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White precipitate produced by the reaction of morphine hydrochloride with ammonia solution dissolves in sodium hydroxide solution due to the presence of the following group in the structure of morphine hydrochloride:

Alcoholic hydroxyl

Phenolic hydroxyl

Keto group

Aldehyde group

Carboxyl group

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A person got poisoned with alcohols. What alcohol derivatives are used for the analysis by gasliquid chromatography?

Alkyl acetates

Alkyl nitrates

Alkyl sulfites

Alkyl sulfates

Alkyl nitrites

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A pharmaceutical analyst identifies the substance of potassium acetate. What reagent confirms the presence of potassium cation in the substance?

Iron (III) chloride

Zinc oxide

Potassium permanganate

Tartaric acid

Sodium hydroxide

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According to SPhU, formaldehyde can be identified when a sample is reacted with chromotropic acid solution in the presence of concentrated sulfuric acid. What colour is formed by this reaction?

Brown

Yellow

Green

Blue

Violet

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Stimulation of beta-cells of the pancreas causes the hypoglycemic effect of the following drug:

Adrenaline hydrochloride

Glibenclamide

Heparin

Prednisolone

Retabolilum

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A patient with Parkinson’s disease has been prescribed a drug with a predominant effect on the dopaminergic system. What drug is it?

Levodopa

Aminazine

Zopiclone

Lorazepam

Droperidol

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Exacerbation of urolithiasis has caused a renal colic in the patient. What drug must be administered to arrest the colic?

Almagel

Neostigmine methylsulfate

Aethimizolum

Siliborum

Drotaverine hydrochloride

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A patient with atopic dermatitis presented to the hospital. Which drug with anti-inflammatory and antiallergic effect should be administered to this patient?

Aethamidum

Insulin

Oxytocin

Retabolilum

Prednisolone

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What solution is used for the detection of iron (II) ions under the SPhU requirements?

Sodium hydroxide

Potassium ferricyanide

Silver nitrate

Lanthanum nitrate

Ammonia

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The manufacturing pharmaceutical company Elema set up its own corporate pharmacy. In this case, it uses the following distribution channel:

Second level

First level

Fourth level

Third level

Zero level

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An analytical laboratory has the task to confirm the presence of ethylenedi-amine in the aminophylline. Which of the following reagents alows to detect ethylenediamine?

Sodium hydroxide

Copper (II) sulfate

Barium chloride

Silver nitrate

Concentrated sulfuric acid

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Help the doctor to select a drug from the group of non-steroidal antiinflammatory drugs, which is an inhibitor of COX-2 and does not damage the stomach:

Celecoxib

Acetylsalicylic acid

Diclofenac sodium

Paracetamol

Indomethacin

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A patient with acute intoxication has been administered a loop diuretic in order to cause the forced diuresis. What drug is it?

Triamterene

Furosemide

Hydrochlorothiazide

Spironolactone

Mannitol

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A hypertensive patient has been administered lisinopril. What side effect is typical for this drug?

Vomiting

Increased appetite

Constipation

Insomnia

Dry cough

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Advise an internship doctor on why iron preparations should not be administered along with antacids:

This causes malabsorption of iron

This increases intoxication with iron preparations

This accelerates elimination of iron preparations

This impairs deposition of iron in the body

This causes increased binding to blood proteins

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Pharmaceutical analyst working at the laboratory of the State Inspectorate for Quality Control of Medicines identifies the drug substance 'Glucose anhydrous'with copper-tartrate solution ( Fehling’s reagent). What colour precipitate is produced?

Black

Red

Blue

Purple

White

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Senior nurse of the surgical department of the city hospital applied to the interhospital pharmacy. Specify the supporting document for the dispension of dressing material from this pharmacy:

Passport

Invoice

Tax invoice

Certificate

Requisition

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Under the SPh of Ukraine, one of the reactions for the detection of calcium cation presence in drugs is the reaction with:

Sulfuric acid

Hydroxylamine

Glyoxal-hydroxyanil

Hydroxyquinoline

Alizarin

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A pharmaceutical analyst working at the laboratory of the State Inspectorate for Quality Control of Medicines identifies 'Thiamine hydrobromide'with the solution of potassium ferricyanide in the alkaline medium. When doing this, he observes a light-blue fluorescence of the alcohol layer in UV light. What product is thus formed?

Thalleioquin

Ninhydrin

Thiochrome

Murexide

Quinoneimine

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Treatment of a patient who has developed an attack of bronchial asthma for the first time should be started with:

Яг-histamine blockers

M-anticholinergic drugs

Inhalation of glucocorticosteroid

Agonists parenterally

Inhalation of ^-agonists

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A patient with acute heart failure and cardiac glycoside intolerance was given an injection of dobutamine. What is the mechanism of its action?

Blockade of K+-, Na+-ATPase

Stimulation of a 1 -adrenoceptors

Stimulation of ^-adrenoceptors

Inhibition of phosphodiesterase

Stimulation of M-cholinergic receptors

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Specify the indicator which measures the total contribution of various solutes to the osmotic pressure of the solution:

Isotonicity

Osmolality

Apyrogenicity

Isoviscosity

Isohydricity

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When setting up a joint-stock company the founders discussed the issues of financial liability. What is the liability of the board members in a joint-stock company?

Unlimited and solidary

Limited to the value of their shares

Limited to the contributions to the statutory fund and their property

Limited to the double amount of deposits

Limited to the amount of deposits

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A pharmacy opens a bank account to store funds and conduct ongoing business transactions. What kind of account should be opened?

Provisional

Investment

Deposit

Letter of credit

Current

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A female patient has a sleep disorder after stress. Which of the following hypnotic drugs should be preferred for the treatment of insomnia?

Phenobarbital

Aminazine

Barbital

Chloral hydrate

Nitrozepam

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Precipitation reactions are used to establish the identity of drugs. Cation of sodium in sodium citrate can be identified by the formation of a white precipitate with:

Potassium ferrocyanide

Iron (III) chloride

Silver nitrate

Potassium permanganate

Barium chloride

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A pharmaceutical analyst analyzes xeroform. Which of the following reagents can he use to identify bismuth in xeroform?

Sodium sulfide

Ammonium hydroxide

Barium chloride

Copper sulphate

Potassium sodium tartrate

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It is required to perform the extraction of medical poisons isolated from the biological material by the method of VP Kramarenko. At the same time, what substance will be extracted from the acidic medium?

Papaverine

Benzonal

Ephedrine

Codeine

Aminazine

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A forensic medicine laboratory received some biological material. It should be tested for the presence of trichlorfon and dichlorvos. For their isolation a toxicologist infuses them with:

Water acidified with sulfuric acid

Water alkalized with ammonia solution

Ethanol acidified with oxalic acid

Propanol acidified with oxalic acid

Chloroform

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Pharmacies prepare injectable solutions. Which solution is prepared without any stabilizer?

Glucose solution

Solution of caffeine sodium benzoate

Novocaine solution

Sodium thiosulfate solution

Sodium bicarbonate solution

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A pharmacy sells medicines. Which of the following medicines is on the list of the controlled substances?

Hydrocortisone acetate

Tramadol

Gentamicin sulfate

Streptocid

Postinor

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A pharmaceutist has to prepare an aqueous extract of medicinal plants. What can be used as a substitute of plant material in the drug preparation?

Tincture

Thick extract

Aromatic water

Liquid extract

Standardized extract concentrate

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A 65-year-old female patient with a fracture of mandible has been prescribed a drug from the group of narcotic analgesics. Specify this drug:

Piracetam

Heparin

Promedol

Furosemide

Cinnarizine

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A hypertensive patient has been prescribed a drug from the group of nonselective betablockers. Specify this drug:

Prazosin

Anapriline

Labetalol

Neostigmine methylsulfate

Adrenaline hydrochloride

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A patient has a history of cholelithiasis. What drug should be administered to prevent biliary colic?

Contrycal

Pancreatin

Magnesium sulfate

Bisacodyl

Almagel

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From the pharmaceutical stock select a reversible anticholinesterase drug to be administered to the patients with atony of the intestine and urinary bladder in the postoperative period:

Dithylinum

Phosphacolum

Proserin

Atropine sulfate

Benzohexonium

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A patient after acute myocardial infarction has been recommended to take acetylsalicylic acid for 3-4 months. What effect of acetylsalicylic acid would be most relevant for this patient?

Spasmolytic

Antiplatelet

Antipyretic

Antiinflammatory

Analgesic

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Rose essential oil is used as an antiinflammatory and antispasmodic agent. It is localized in the following excretory structures:

Glandular spots

Glandular hairs

Secretory cells

Essential oil conceptacles

Essential oil glandules

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Production, labour and socioeconomic relations between the head of a pharmaceutical company and the workforce are regulated by:

Statute

Collective agreement

Contract

Labour contract

Corporate code

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A pharmacy makes bulk purchases of health and hygiene products. The agent works under a contract with the manufacturer and operates on his account. The agent may be given the exclusive right to sell goods in certain regions. Specify this agent:

Consignee

Wholesale agent

Dealer

Broker

Commission agent

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A pharmaceutical company has made a decision to expand its activities. The process of the company’s activity expansion by penetration into new fields of the branch is called:

Segmentation

Conglomeration

Integration

Centralization

Diversification

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A pharmacy prepares ointments with extracts. What is the way to incorporate the dry and thick extracts into the ointments?

To triturate them first with alcohol-water-glycerol [1:6:3] mixture

To disperse them with ethanol

To incorporate them directly into the molten ointment base

To dissolve them in water first

To disperse them with a liquid which is compatible with the base

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A pharmacy received a prescription: Rp.: Dibazoli0,05 Papaverini hydrochloridi 0,15 Sacchari 2,5 M. fiat pulv. Divide in partes aequales №10. Specify the weight of a single powder dose :

0, 25

2, 7

0, 30

0, 26

0,27

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A pharmaceutist working at an analytical laboratory is engaged into sulfite-ion identification of a drug in compliance with the requirements of SPhU. What reagent becomes colourless in this study?

Potassium nitrate solution

Iron (III) chloride solution

Ammonia solution

Iodine solution

Potassium iodide solution

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Select a drug for the treatment of bronchial asthma from the group of fi2-agonists:

Salbutamol

Ketotifen

Aminophylline

Beclomethasone

Atrovent

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Ampules are produced of glass with appropriate heat resistance. An ampule would meet the requirements of technical standards if the ampule glass has the following characteristic:

Easy cutting of capillaries

Withstanding the stresses during production and transportation

Protection of light-sensitive materials

Quality ampule sealing

Thermal shock resistance

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Ampule quality control involves testing for chemical resistance. What methods are used to test this indicator?

Autoclaving followed by titration with a solution of hydrochloric acid

Exposing the glass samples to the action of sodium carbonate and sodium hydrocarbonate solutions

Various acid-base indicators, pH meter, gravimetric methods

Visual, gravimetric methods

Photoelastic method

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A pharmaceutist prepared the massage cream of the following composition: Beeswax 12,0 Almond oil 68,5 Spermaceti 12,0 Anhydrous lanolin 7,5 Essential oil of lavender 3 drops. Specify the cream type:

Emulsion

Non-oily

Combined

Suspension

Oily

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What is the function of anhydrous lanolin in the suppository mass used for suppositories prepared by hand rolling?

Solvent

Plasticizer

Emollient

Solubilizer

Preservative

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Plantain leaves are used for production of Plantaglucidum which has antiulcerogenic action. The plant material analysis involves quantitative determination of the following class of compounds:

Carotenoids

Amarines

Vitamins

Polysaccharides

Terpenes

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What herbal drug produced form alkaloid-containing raw materials can be recommended for neurasthenia, insomnia, menopausal disorders?

Securinine nitrate

Novopassit

Vinblastine

Glaucine hydrochloride

Ergotamine

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A pharmaceutist has prepared a suspension with a hydrophobic substance. What stabilizer is required for its preparation?

5% solution of methyl cellulose

Sodium thiosulfate

Sodium chloride

Glucose

Polyethylene oxide

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A patient has been found to have pesticide intoxication. Biochemical (cholinesterase) test was positive. What pesticide is likely to have caused the intoxication?

Hexachlorocyclohexane

DDT

Ethyl mercury chloride

Heptachlor

Dichlorvos

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Which of the following sublingual drugs quickly relieves an attack of stenocardia?

Amiodarone

Corglycon

Lisinopril

Digoxin

Nitroglycerine

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Diazepam is used for the treatment of neuroses due to the following pharmacological effect:

Anxiolytic

Diuretic

Antipyretic

Analgesic

Antidepressant

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A patient has been administered a spasmolytic from the group of muscarinic receptor antagonists as a part of the complex treatment for renal colic. Specify this drug:

Galantamine

Neostigmine

Atropine

Benzohexonium

Dithylinum

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One of the recent industrial medical forms that is used in pediatric practice and intended for young children unable of swallowing tablets is:

Tubatines

Granules

Spansules

Dragee

Gelatin microcapsules

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What final document is used for the preparation of the report on the discrepancies revealed in course of the inventory at the pharmacy?

Checklist

Act on the inventory results

Commercial report

Inventory item description

Invoice

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Pharmaceutical market of Ukraine comprises pharmacies of various forms of ownership. Specify the form of ownership for a community pharmacy:

Workforce of an enterprise

-

Territorial community

Private person

Group of shareholders

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A patient with a history of allergic rhinitis has been prescribed ephedrine in form of nasal drops. The patient has significantly benefited from nasal instillation, and this stimulated him to use the drug every two hours. But under these conditions the drug appeared to be ineffective. What is the most likely cause of this phenomenon?

Allergy

Drug dependence

Cumulation

Idiosyncrasy

Tachyphylaxis

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A pharmaceutic plant producing aerosol forms uses liquefied gases as propellents. Which of the following substances relates to the group of liquefied gases?

Nitrogen

Ethylene chloride

Freons

Nitrous oxide

Methylene chloride

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A pharmaceutist has to prepare a drug by the prescription: Rp.: Natrii hydrocarbonatis 2,0 Natrii benzoatis 1,5 Liquoris Ammonii anisatis 4 ml Aquae Mentae 100 ml M.D.S. 1 tablespoon 3 times a day. Specify the component that is added in the first place :

Liquoris Ammonii anisatis

Sodium hydrogen carbonate

Sugar syrup

Sodium benzoate

Mint water

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A person got poisoned with an unknown substance. Chemico-toxicological test for the isolated toxin with Dragendorff’s, Sonnenschein’s, Schei-bler’s reagents caused setting of sediments. The specific study should be focused on the following group of toxic substances:

Ammonia and its salts

Hydrocyanic acid

Methyl alcohol

Alkaloids and nitrogen-containing compounds

Metal toxins

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A laboratory for drug quality control checks the quality of the drug substance nitrofural ( furacilin). The chemical denomination of this drug is :

1-(5- Nitrofurfurilidenamino)imidazolidine-2,4-dione

5-Nitro-2-furaldehyde semicarbazone

N(-(2-Furantdil)-5-fluorouracil

7- Nitro-5-phenyl-1,3-dihydro-2H-1,4-benzodiazepin-2-one

1,2-Diphenyl-4-butylpyrazolidine-dione-3, 5

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A 25-year-old patient with frequent migraine attacks has been prescribed sumatriptan. Specify the mechanism of its action:

Selective agonist of 5 — HTi-serotonin receptors

Selective «-blocker

Selective antagonist of 5 — HTX-serotonin receptors

Stimulator of в-adrenergic receptors

Nonselective «-blocker

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A 43-year-old patient with a severe form of rheumatoid arthritis has been administered a certain drug for background therapy. Specify this drug:

Prednisolone

Methotrexate

Nimesulide

Diclofenac sodium

Methylprednisolone

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In order to analyze marketing opportunities and make a forecast of the market position a pharmaceutical company can use a matrix allowing the company to find new markets ( geographical) or identify new areas of using traditional medicines. What matrix is used by a pharmaceutical company to identify its market position?

Porter’s matrix

Matrix of competitive advantages

Competitive force models

Boston Consulting Group matrix

Ansoff matrix

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A female 49-year-old patient complains of compressing headache in the occipital region, dizziness, increased AP. The patient has a history of diabetes melli-tus type II. What diuretic DOES NOT affect the blood glucose level?

Indapamide

Urea

Ethacrynic acid

Furosemide

Hypothiazide

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A 65-year-old patient complains of nausea, vomiting, lethargy, seeing yellow spots in front of his eyes. The patient daily takes 0,25 mg of digoxin, 100 mg of aspecardum, 50 mg of metoprolol. What pathological condition is this syndrome typical for?

Withdrawal syndrome

Tachyphylaxis

Hypersensitivity reaction

Food poisoning

Glycoside intoxication

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Pharmaceutical plants produce ointments on various bases. Specify the ointment base having the most pronounced osmotic properties:

Hydrogenated fat

Methyl cellulose

Silicon

Polyethylene oxide

Vaseline, lanolin

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Ampule workshop of a pharmaceutical factory produces the procaine hydrochloride solution. This solution is stabilized by adding:

20,0 of sodium hydrogen carbonate

0,1 mol/l of hydrochloric acid solution

1,5 g of amino-propylene glycol

0,1 mol/l of sodium hydroxide solution

0,1 mol/l of sodium hydrogen carbonate solution

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Some alkaline solution was added to the alcohol solution of ftivazide, causing the solution to change colour from the light yellow to the orange-yellow. Subsequent addition of hydrochloric acid made the solution become again light yellow, and then orange-yellow. What properties of ftivazide are proved by this reaction?

Base

Oxidative

Amphoteric

Acid

Reducing

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When atropine sulfate is tested for purity, the alkaloids and degradation products are detected by TLC. For this purpose the chromatographic plate is sprayed with a solution of:

Potassium iodobismuthate

Tetrabutylammonium hydroxide

Acetic-hydrochloric dini- trophenylhydrazine

Ammonia

Ninhydrin

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Specific impurity of thiosulfates in Natrii iodidum and Kalii iodidum is identified by adding starch and iodine solutions. The absence of impurities is proved by:

White precipitate

Blue colour

Disappearance of the blue colour

Discolouration of the solution

Yellow colour

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Bronchodilatory effect of shortacting ^2-adrenoceptor agonist salbutamol develops after:

2-3 hours

45-60 minutes

20-30 minutes

5-10 minutes

4-6 hours

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A12 weeks pregnant patient has been hospitalized with symptoms of acute cystitis. What antibiotic can be recommend in this case?

Amoxicillin

Gentamicin

Ciprofloxacin

Metronidazole

Tetracycline

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Issuing prescriptions and orders for drugs and medical products is regulated by the Order № 360 dated 19.07.2005 (as amended). Specify the prescription form for phenobarbital as a part of a combined dosage form:

F-2

F-3 in duplicate

Prescription forms F-1 and F-3 in duplicate

F-1

No prescription

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Vacation leaves for employees of pharmacies include paid annual, additional, sabbatical, social leaves, as well as unpaid leaves. What is the total duration of the paid basic and additional vacation leave?

60 calendar days

65 calendar days

59 calendar days

70 calendar days

90 calendar days

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Representatives of the family Solanaceae are widely used in medical practice as alkaloidcontaining plants. Which representative is the source for production of semi-synthetic steroid hormones?

Solanum tuberosum

Atropa belladonna

Datura Stramonium

Hyoscyamus niger

Solanum laciniatum

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After harvesting the calamus rhizomes the received material should be dried. What temperature range is required for obtaining good-quality raw material?

35-40°C

70-80 °C

80-90 °C

40-60 °C

60-70 °C

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A pharmaceutist has to prepare 10% alcohol solution of iodine. What is the required concentration of ethanol for this purpose?

96 %

70 %

40 %

95%

60 %

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Field horsetail grass is recommend as a diuretic. What herbal material can be used as a substitute?

Herba Leonuri

Herba Adonidis

Herba Convallariae

Herba Aervae lanatae

Herba Menthae piperitae

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A pharmaceutist prepares an infusion at a ratio of 1:30. What plant material would be used?

Sage leaves

Marshmallow root

Lily of the valley grass

Shoots of Marsh Labrador tea

Oak bark

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Under the SPhU (appendix 2), leaves of ginkgo are standardized by the content of:

Chromones

Flavonoids

Coumarins

Saponins

Alkaloids

‹ Назад

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The pharmaceutical market is characterized by the seasonal fluctuations in demand for anticold medicines. What kind of marketing is used in case of such demand?

Remarketing

Conversive

Counteractive

Developing marketing

Synchromarketing

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Economic analysis of pharmacy activity involves a number of absolute indices. What index is determined by the formula: 'income from sales - prime cost of goods':

Net profit

Level of costs

Total balance

Gross profit

Amount of costs

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Salicylic acid and its derivatives may be the cause of acute intoxication. When salicylates are analyzed by TLC method, the chromatographic plate is sprayed with:

Marquis reagent

Solution of iron (III) chloride

Forrest reagent

Dragendorff’s reagent

Solution of mercury (II) sulfate and chloroform solution

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The simple sugar syrup consists of:

50 parts of sugar and 50 parts of water

45 parts of sugar and 55 parts of water

64 parts of sugar and 36 parts of water

73 parts of sugar, 22 parts of water, 5 parts of 90% alcohol

65 parts of sugar, 33 parts of water, 2 parts of 90% alcohol

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Prescriptions for the controlled drugs dispensed under the reimbursement program (except for the narcotic and psychotropic preparations in substance) are issued on the following prescription form:

№1 in duplicate

№1 and № 3

№3 in duplicate

№3, single copy

№1, single copy

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Quarterly evaluation of business and financial performance of a pharmacy involves calculating its profitability. For this purpose the following data is used: turnover - 100 thousands UAH, gross profit - 25 thousands UAH, expenditures -1 thousand UAH. Calculate the profitability of the pharmacy:

20 %

25 %

10 %

15%

22 %

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A patient suffering from epilepsy has taken phenobarbital for a long time and developed drug tolerance. What is the mechanism of this phenomenon development?

Receptor’s sensitivity enhancement

Accumulation of substances in the body

Inhibition of biotransformation

Absorption process reduction

Acceleration of biotransformation

‹ Назад

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Who is responsible for the acceptance of goods and medical products with accompanying incoming quality control?

Authorized representative

Supplier pharmaceutist

Head of pharmacy

Analyst

Pharmaceutist

‹ Назад

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During steam distillation of voltile poisons the first portion of the distillate is collected in a receiver with 2% solution of sodium hydroxide. It is used to detect:

Ethanol

Cyanides

Formaldehyde

Acetates

Phenol

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Alkaloid glaucine has an antitussive effect that is stronger and longer if compared to that of codeine, and exhibits no narcotic side effects. What drug plant contains glaucine?

Thermopsis lanceolata

Yellow hornpoppy

Datura

Celandine

Henbane bell (Scopolia carniolica)

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A pharmacy has no quinquelobate motherwort in stock. It can be substituted by the following herbal material:

Raspberry fruits

Hypericum grass

Beggarticks grass

Linden flowers

Rhizomes and roots of valerian

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Drug plant Dioscorea nipponica is the source for production of Polysponi-num drug which is used in the complex treatment of atherosclerosis. Specify the active compounds of dioscorea material:

Steroidal saponins

Cardiac glycosides

Triterpene saponins

Essential oil

Alkaloids

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A drug raw material from the family Polygonaceae had been sent to a laboratory for analysis. On macroscopic examination the material was identified as a herbaceous plant with lanceolate leaves with a red spot, and filmy ocreae covered with appressed hairs. The plant had the apical inflorescence in dense spicate panicles. What plant is it?

Redshank (persicaria)

Biting knotweed

Snakeweed

Common buckwheat

Common knotweed

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A 35-year-old patient with tachycardia has been administered propranolol. Which of the following reactions may be caused by the use of beta-blockers?

Drug dependence

Bronchospasm

Constipations

Cumulation

Blood pressure rise

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Under the SPhU requirements mercury salts are indentified by means of interaction with sodium hydroxide solution. Specify the colour of the precipitate that is produced as a resut of this reaction:

Red

Yellow

Yellow-green

Blue

White

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A 17-year-old patient complains of persistent thirst, dry mouth, frequent urination, increased appetite. Blood glucose is at the rate of 11 mmol/l. The patient has been diagnosed with diabetes melli-tus type I. What drug is indicated for treatment?

Maninil

Glibenclamide

Asparcamum

Acarbose

Insulin

‹ Назад

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A pharmacy serves the polyclinics of a city district. Specify the bill of materials that shows the number of drugs dispensed on prescriptions of the doctors who work in the polyclinics:

-

Inpatient

Outpatient

Polyclinic

Medical

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At the end of the reporting period a pharmacy makes an analysis of its commercial and financial activities. What economic index describing the commercial and financial performance is defined as the ratio of the pharmacy profit to the turnover?

Retail turnover

Bill of material

Distribution costs

Wholesale turnover

Profitability

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Phytochemical workshop of a factory manufactures pancreatin. What is the source material for obtaining pancreatin?

Heart of cattle

Egg white

Pancreas of pigs or cattle

Lungs of cattle

Gastric mucosa of pigs

‹ Назад

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Which of the following diuretics SHOULD NOT be administered to patients with impaired hearing?

Clopamide

Chlorthalidone

Indapamide

Furosemide

Spironolactone

‹ Назад

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A patient who has been taking acetylsalicylic acid developed hemorrhages of mucous membranes. This phenomenon is associated with:

Changed volume of distribution

Inhibition of the prothrombin synthesis

Disorder of protein binding

Increased absorption in the gastrointestinal tract

Decreased absorption in the gastrointestinal tract

‹ Назад

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Simultaneous use of paracetamol and acetylcysteine causes:

Inhibition of paracetamol absorption

Reduction of paracetamol hepatotoxi-city

Reduction of anti-inflammatory action of paracetamol

Increase of paracetamol nephrotoxicity

Increase of mucolytic action of acetylcysteine

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Simultaneous use of gentamicin and acyclovir tablets increases the risk of:

Nephrotoxicity

Likelihood of allergic reactions

Neurotoxicity

Hepatotoxicity

Cardiotoxicity

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Simultaneous use of doxycycline hydrochloride and oral contraceptive causes:

Reduction of the antibacterial effect of doxycycline

Reduction of oral contraceptives effectiveness

Increase of oral contraceptives effectiveness

-

Increase of the antibacterial effect of doxycycline

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In case of simultaneous use of metronidazole and oral anticoagulants derived from coumarin patients must be warned about:

Reduction of metronidazole effect

Potentiation of anticoagulants effect and the risk of bleeding

Reduction of anticoagulants effect

Higher neurotoxicity

Potentiation of metronidazole effect

‹ Назад

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Business transactions of pharmacies are reported in the accounts. Specify the account that reports the settlements with debtors and creditors:

Positive

Business

Trial balance

Negative

Nominal

‹ Назад

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Apart from goods sales, there are other business transactions that can be characterized as goods disposal. Which of the following business transactions reduces the stock at pharmacies?

Reclassifying other supplies as goods

Bringing the oversupply on charge

Revaluation for the packing and laboratory work

Bringing the glassware on charge

Disposal of products for economic needs

‹ Назад

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A pharmaceutical analyst analyzes the substance of ascorbic acid in compliance with the requirements of the State Pharmacopoeia of Ukraine. To identify the oxalic acid impurities he uses the solution of:

Sodium thiosulfate

Sodium chloride

Calcium chloride

Sodium sulfate

Sodium hydrocarbonate

‹ Назад

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Phenobarbital drug has a sedative, hypnotic and anti-epileptic effect. What is its international nonproprietary name?

Salol

Nitrofurazone

Chloramphenicol

Luminal

Diazepam

‹ Назад

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A 70-year-old patient with stenocardia claims that the pharmacy sold him a drug that relieved an attack of stenocardia but instead caused an acute bursting headache. What antihypertensive drug is this side effect typical for?

Nitrosorbid

Nifedipine

Amlodipine

Metoprolol

Trimetazidine

‹ Назад

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During the working day a pharmaceutist prepared five dosage forms. Which of them requires a complete chemical control?

5 % aethonium solution

Mixtura Pavlovi

Eye drops 10 ml of 2% ethylmorphine hydrochloride solution

Antipruritic ointment

Ear drops with levomycitin

‹ Назад

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Commercial and financial activity of a pharmacy involves using returnable tare. Which of the following containers are returned to the supplier?

Glassware

Paper boxes

Metal cylinders

Packaging materials

Glass-stoppered bottles

‹ Назад

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A pharmacy plans to expand the production of medicines. For this purpose it purchased the production equipment at a cost of 7000 uAh. The cost of the equipment will be recorded to the balance of the pharmacy as:

Fair value

Revalued amount

Initial cost

Residual

Amortization cost

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An accountant of a pharmacy issued a cash receipt voucher for the sales proceeds. What document is used to register cash receipt and cash payment vouchers before the cash arrives to the cashiers?

Cash book

Cash report

Pay list

Register of receipt and payment cash documents

Ledger of cash dispensed and received by the senior teller

‹ Назад

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Biochemical blood test revealed low level of serum iron. What disease are these changes typical for?

Pneumonia

Bronchiectasis

Bronchial asthma

Iron-deficiency anemia

Acute bronchitis

‹ Назад

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A patient who has been treated for hypertension complains of cough. Objective examination reveals no changes in the lungs. Which of the following drugs might have caused cough?

Captopril

Nebivolol

Clonidine

Hypothiazide

Amlodipine

‹ Назад

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What non-narcotic antitussive drug of central action can be used for dry cough?

Glaucine

Ambroxol

Acetylcysteine

Mucaltin

Codeine

‹ Назад

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Galenic preparations are produced by using various extractants. What extractants require pressure as a prior condition for the extraction process?

Methyl alcohol, acetone

Dichloroethane, chloroform

Vegetable oils

Ethanol

Liquefied gases

‹ Назад

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Menthol has anesthetic and antiseptic effect. What plant is the source of menthol?

Folia Menthae piperitae

Folia Salviae

Folia Eucalypti

Folia Absinthii

Folia Uvae ursi

‹ Назад

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Hydrocyanic acid and its salts are extremely toxic substances. In humans, they are partly neutralized by enzymatic conversion into:

Thiocyanate

Nitrogen (II) oxide

Acetic acid

Carbon (IV) oxide

Ethanol

‹ Назад

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Methyl alcohol which is widely used in industry causes severe health disorders when enters the human body even in small amounts. This effect is induced by the action of the following major metabolites of methanol:

Acetic acid and acetaldehyde

Ethyl alcohol and ethyl acetate

Ethanol and acetaldehyde

Formaldehyde and formate acid

Methyl acetate and ethyl acetate

‹ Назад

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Enrolled in private pharmacies to implement a drug whose active ingredient is the chemical name of 2-chloro-10-(3’-dimethylaminopropyl)-phenothiazine hydrochloride. Specify this drug:

Clonidine hydrochloride

Promethazine hydrochloride

Diphenhydramine hydrochloride

Chlorpromazine hydrochloride

Trifluoperazine hydrochloride

‹ Назад

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The thyme grass is used for the production of herbal medical products for the treatment of respiratory tract infections. Under the SPhU, the herbal raw material is subject to chromatographic identification by means of thin layer chromatography. What substances are detected on the chromatographic plate after its treatment with due reagent?

Quercetin and rutin

Arbutin and methyl arbutin

Thymol and carvacrol

Apigenin and luteolin

Atropine and hyoscyamine

‹ Назад

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Flower buds of clove contain the essential oil used for production of herbal antiseptics. Under the State Pharmacopoeia of Ukraine, the raw materials are identified by the method of thin layer chromatography. What zones can be identified on the chromatographic plate after their treatment with reagent?

Quercetin and rutin

Apigenin and luteolin

Scopoletin and umbeliferon

Hyoscyamine and scopolamine

Eugenol and caryophyllene

‹ Назад

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Specify the base for the preparation of antibiotic ointments:

8 parts of vaseline + 2 part of lanolin

5 parts of vaseline + 5 part of lanolin

6 parts of vaseline + 4 part of lanolin

5 parts of vaseline + 1 part of lanolin

7 parts of vaseline + 3 part of lanolin

‹ Назад

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Business transactions of a pharmacy are recorded in the control accounts as listed in the chart of accounts. The balance on the ledger and sub-ledger accounts is used to fill out the following document:

Profit and loss account

Assets

Fourth section of the liabilities side

Liabilities

First section of the liabilities side

‹ Назад

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A 40-year-old patient has a history of bronchial asthma and heart rhythm disorders in form of bradyarrhythmias. Bronchospasm can be eliminated by the drugs of the following pharmacological group:

M-cholinergic antagonists

в-blockers

M-cholinomimetics

Muscle relaxants

Cholinesterase inhibitors

‹ Назад

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