Step 2 - Pharmacy 2013

It is required to prove the presence of bismuth ions in the mineral residue. What preliminary reaction is used for this purpose?

With potassium chromate

With 8-hydroxyquinoline

With copper acetate

With dithizone

With sodium rhodizonate

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A pharmacy prepared a solution of macromolecular substance with limited swelling capacity. What solution was labelled 'warm up before use'?

Trypsin

Pancreatin

Gelatin

Methyl cellulose

Pepsin

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A pharmacy rceived a prescription for ethyl alcohol. What amount of alcohol can be dispensed to the patient with diabetes free of charge?

100 g per month

150 g per month

There is no standard

200 g per month

50 g per month

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Schedule of sanitation actions in pharmacies is regulated by the relevant regulatory acts. Cleaning day at a pharmacy must be scheduled for at least 1 time:

In a week

In a month

In 3 days

In 10 days

In 5 days

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6 months after treatment a patient with coronary heart disease developed tolerance to the prolonged-action nitrates. What drug with nitrate-similar effect should be recommended in this case?

Prazosin

Metoprolol

Nifedipine

Verapamil

Molsidomine

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Losartan for treatment of arterial hypertension is contraindicated in case of:

Urine acid diathesis

Hyperlipidemia

Hypokalemia

Pregnancy

Hyperglycemia

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A patient with hypertensive crisis has been given an intravenous injection of clonidine. What mechanism underlies the antihypertensive effect of clonidine?

Direct myotropic effect on blood vessels

Stimulation of the central presynaptic a2-adrenergic receptors

Blockade of N-cholinergic receptors

Blockade of peripheral a-adrenergic receptors

Blockade of в-adrenergic receptors

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A patient with the symptoms of cardiac glycoside intoxication has been administered unitiol. What is the mechanism of therapeutic action of this drug?

Binding of the ionized Ca2+

Induction of cardiac glycosides metabolism

Increase in Na+ level in the myocardium

Reactivation of the membrane K +, Na+-ATPase

Increased penetration of K + into the cardiac myocytes

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A 38-year-old male patient with mercuric chloride intoxication has been delivered to the admission ward in grave condition. What antidote must be immediately administered the patient?

Unithiol

Dipyroxime

Nalorphine

Izonitrozinum

Atropine

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Standard herbal material of lily-of-the-valley is obtained by drying it at a temperature of 50-60 oC in order to prevent the following possible biochemical process :

Oxidation of phenolic compounds

Enzymatic hydrolysis of cardiac glycosides

Oxidation of terpenoids

Oxidation of resins

Volatilization of essential oils

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Which drug including the beta-lactam cycle in its structure gives a positive reaction with a solution of hydroxylamine hydrochloride in the presence of sodium hydroxide followed by adding the solution of iron (III) chloride?

Papaverine hydrochloride

Phenoxymethylpenicillin

Antipyrine

Dibazolum

Streptocid

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A pharmaceutical plant produces spi-ssum extract with 0,25% ammonia solution used as an extractant. This is a spissum extract of:

Sagebrush

Male fern

Motherwort

Valerian

Licorice

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A person got poisoned with the lead compounds. What is the most sensitive method of the quantitative analysis of lead ions?

Photometry

Dichromate iodimetry

Chelatometry

Atomic absorption spectrometry

Gravimetry

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A marketing manager of a pharmaceutical company carries out market research on vitamin preparation market. He takes into account various parameters including the therapeutical effectiveness, supply and demand. What method should be applied?

Delphi method

Graph method

Mathematical statistics method

-

Method of extraction from the original medical records

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A factrory workshop producing suspensions and emulsions is going to develop the manufacture of new drugs. What mechanisms can be used for the ultrasound processing of drugs?

Dismembrator, electrical impulse plasmolyzer

Disintegrator, liquid whistle

Rotor-pulsation apparatus, di-smembrator

Centrifugal mixer with rotating housing

Liquid whistle, magnetostrictive source

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A pharmaceutist prepared a lipophilic ointment of suspension type. What substance is used for preparing this kind of ointments?

Protargolum

Herbal extracts

Menthol

Xeroform

Tannin

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A pharmaceutist has a labour dispute with the pharmacy administration about rescheduling his annual vacation leave. The employee can appeal against the decision of the pharmacy administration to the following body:

Labour disputes commission (LDC)

Trade union committee

Highest management bodies of pharmaceutical service at the regional level

Commercial court

MoH of Ukraine

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Medications Passit and Novopassit are used as tranquilizing, sedative and mild hypnotic agents. These medications are produced from the following grass:

Three-lobe beggarticks

Lesser periwinkle

Elecampane

Purple passionflower

Garden sage

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During transportation, the markings on the packages of theobromine and theophylline were damaged. What solution allows to identify theobromine and theophylline?

Potassium permanganate

Copper nitrate

Potassium dichromate

Cobalt chloride

Sodium chloride

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Which of the following antihypertensive drugs has potassium-sparing action?

Triamterene

Metoprolol

Furosemide

Diltiazem

Prazosin

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What drug acts as a specific antidote in case of iron drug intoxication?

Bemegride

Deferoxamine

Protamine sulfate

Penicillamine

Atropine

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A regional medical representative of a foreign company uses the data derived from periodicals and reference and statistical materials in order to characterize the territorial pharmaceutical market. What kind of market research is based upon these sources?

Field studies

Desk studies

This method does not apply to research

All answers are correct

-

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A pharmaceutist was on a business trip. What is the deadline for submitting a travel expense report?

A week after returning from a trip

There is no deadline

Four working days after returning from a trip

Ten working days after returning from a trip

Three working days after returning from a trip

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An accountable person (accountant) has been given some cash from the cash account of the company for the purchase of stationery goods . What is the deadline for submitting a full statement of the accountable person on the cash use after receiving the cash?

Five working days

One week

Third banking day

Ten working days

There is no fixed term

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A pharmaceutist prepares trituration of atropine sulfate. What adjuvant should be used for this purpose?

Saccharose

Glucose

Talc

Lactose

Starch

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A pharmaceutical factory produces tablets of sodium chloride. What is the method of their poduction?

Direct compression with the addition of excipients

Moulding

Dry granulation prior to compression

Wet granulation prior to compression

Direct compression without additional substances

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A pharmaceutical factory produces suspensions and emulsions. Specify the equipment which is used for dispersion and mixing in the liquid medium:

Oscillating mixers

Drum mixers

Gate mixers

Anchor mixers

Rotor-pulsation apparatus, colloid mixers

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A pharmaceutist prepared eye drops containing silver nitrate. What substance must be taken to ensure isotonicity?

Sodium chloride

Sodium nitrate

Sodium sulfate

Boric acid

Glucose

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In order to detect the presence of thiosulfate ions a pharmaceutical analyst added the excess reagent. The resulting reaction produced a white precipitate, which slowly turned yellow, then brown, and black. What solution was added?

Lead (II) acetate

Ammonium oxalate

Silver nitrate

Barium chloride

Diphenylamine

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Collective labour agreement is concluded by a trade union committee with the enterprise owner on behalf of the workforce. Any collective agreement is worked out in written form. Which article of the Labor Code regulates the duration of the collective agreement?

38

41

17

36

40

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A person got poisoned with salts of manganese. Analysis of the mineral residue revealed manganese ions. What reactions underlie the chemical processes of manganese detection?

Neutralization

Dissociation

Hydrolysis

Metathesis

Oxidation-reduction

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A pharmaceutist prepares a solution for injections that must be stabilized with 0,1M of hydrochloric acid solution. What solution is to be prepared?

Novocaine

Potassium chloride

Calcium chloride

Hexamethylenetetramine

Sodium benzoate

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Paracetamol substance has been sent for analysis. Reaction with the solution of iron (III) chloride gave the blue-purple colour. This indicates the presence of:

Ester group

Keto group

Alcoholic hydroxyl

Phenolic hydroxyl

Aldehyde group

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Production of tablets requires stage-to-stage quality control. What devices are used to determine the particle size distribution (fraction) of granules?

Friabilators

Various vibrosieves

Laboratory IDs

Standard set of sieves

Microscope

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Analysis of the drug sales performance revealed market expansion, the absolute increase of the drug in manufacturer’s stocks, slowdown in the growth rate of sales, intense competition. What stage of the product life cycle is the drug in?

Maturity

Development

Growth

Introduction

Saturation and decline

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Anthracene derivatives of emodin have purgative effect. Large quantities of anthracenederived groups of emodin are contained in the fruits of the following plant:

Elder (Sambucus)

Blueberry (Vaccinium myrtillus)

Blackcurrant

Buckthorn

Alder buckthorn (Frangula alnus)

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Theory of management currently points out four the most important approaches to the management. Select the approach that is NOT applied in the theory of management:

Systemic

Process approach

Situational

Structured

Different schools dedication approach

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A pharmaceutist worked on a holiday, and the time worked was within the normal working hours of the current month. The employee would be entitled to be paid:

Single piecework rate

Fixed salary + double daily rate

According to the standard procedure as for a normal working day

Fixed salary + one daily rate

There would be no penalty rates

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A pharmacy has a license for selling narcotic drugs. The warrant for the receipt of these drugs from the pharmacy warehouse is valid for:

No longer than five calendar days from the date of issue

No longer than one calendar days from the date of issue

No longer than three months from the date of issue

No longer than one year from the date of issue

No longer than 10 calendar days from the date of issue

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Help the doctor to select a drug for the replacement therapy after the thyroid gland removal:

Mercazolilum

Parathyroidin

Insulin

Prednisolone

L-thyroxine

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Chloride of lime is identified by calcium cations after boiling with acetic acid in order to eliminate active chlorine. What reagent is used?

Magnesium sulfate

Ammonium molybdate

Sodium nitrite

Potassium chloride

Ammonium oxalate

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The medicine 'Bismuthi subnitras'can be identified after dissolving it in the acid with the following reagent:

Potassium iodide

Sodium chloride

Potassium chlorate

Potassium nitrate

Sodium sulfate

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Sterilization methods used for the preparation of drugs under aseptic conditions can be differentiated into physical, mechanical, and chemical ones. Specify the chemical method of sterilization:

Dry heat sterilization

Addition of preservatives

Radiation sterilization

Pressure steam sterilization

UV light sterilization

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Activity of a company leader involves managerial decision-making aimed at the achievement of corporate goals. Which of the following decisions are NOT classified by the method of justification?

Decisions based upon judgements

Rational

Intuitive

-

Standard

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Pharmacies prepare triturations of toxic and superpotent substances. They can be prepared in a following ratio:

1:100 only

1:1000

1:10 and 1:100

1:10 only

1:500

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It is required to prepare furacilin solution (1:5000). What is the dissolution peculiarity of furacilin?

It dissolves in the cold purified water

It dissolves in the filtered purified water

It dissolves in the boiling water purified in the presence of sodium chloride

It dissolves in the purified water after the trituration

It dissolves in a minimal amount of ethyl alcohol

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The method of suspension preparation depends on the properties of its components. Specify the substances having hydrophobic properties:

Zinc oxide, talc

Camphor, menthol

Sodium bicarbonate, sodium sulfate

Boric acid, calcium carbonate

White clay, bentonite

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A patient has been prescribed hand-rolled rectal suppositories with 0,1 g of aminophylline. What is the amount of base required for each suppository, provided that the suppository weight is not specified in the formulation?

1,9 g

3,9 g

2,4 g

2,9 g

1,4 g

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Pharmaceutical depot received a batch of herbal material of cinnamon rose. What substance determines the quality of the raw material?

Tannins

Coumarins

Ascorbic acid

Anthracene derivatives

Essential oil

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A pharmaceutist prepares an ointment on a hydrophobic base. What substance does he use in order to reduce the melting point of the base?

Vaseline oil

Glycerol

Dimexide

Ethanol

PEG-40

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In order to identify deoxycorticosterone acetate a pharmaceutical analyst performed a steroid cycle reaction, which resulted in formation of cherry-red colour and a green fluorescence. What reagent was added?

Iron (III) chloride solution

Potassium hydroxide solution

Chloroform

Concentrated sulfuric acid

Iodine solution

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An analytical laboratory received a sample of alpha-aminobutyric acid for analysis. What reagent should be used by the analyst in order to identify this substance?

Aniline

Ninhydrin

Benzene

Calcium bromide

Sodium nitrate

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A retail pharmacy has been purchasing goods within an accounting period. What changes to the balance will result from this business transaction?

Increase in assets and liabilities

Changes will be caused to the assets only

Changes will be caused to the liabilities only

-

Decrease in assets and liabilities

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Leaves of greater plantain are harvested in summer by mowing or cutting them with a knife or a sickle. There is always one developed plant left per 1 m2. The plant is harvested in the following vegetation period:

Rosetting

Beginning of fruiting

Ripeness

Budding

Blooming

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A manufacturing enterprise plans to sell a new drug through the corporate chain of pharmacies. What strategy of drug distribution would be used?

Flexible

Horizontal integration

Direct

Multi-echelon

Vertical integration

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The quality of tablets is assessed by various factors. What instrument is used for the tablet disintegration test?

Basket apparatus

Friabilator

-

Paddle

Flow-through device

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A pharmaceutical manufacturer develops a system of product. The focus is laid on the maximum involvement of agent network. What type of marketing is applied?

-

Exclusive

Combined

Selective

Intense

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While preparing marshmallow root extract, a pharmaceutist mistakenly used the water of improper temperature for this extract, and the end product came up turbid. What is the required water temperature for the extraction of this herbal material?

60 oC

100 oC

40 oC

Room temperature

80 oC

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A 67-year-old patient with chronic heart failure takes digoxin. In order to reduce its side effects the patient’s doctor recommended to combine it with the followig drug:

Panangin

Hydrochlorthiazide

Calcium gluconate

Calcium chloride

Euphyllinum

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A certain plant is used for production of tinctures and extracts which are the part of complex drugs Bellataminal, Becarbon, Besalol, etc. Specify the grass that is used for this purpose:

Celandine

Beggarticks

Astragalus

Belladonna

Lily of the valley

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A woman who has been treated for infiltrative focal tuberculosis for a long time complains of acute hearing impairment. Which of the following preparations might be the cause of this side effect?

Streptomycin

Ethambutol

Isoniazid

Rifampicin

Ethionamidum

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A pharmaceutist prepared a drug by the prescription: Rp.: Streptocidi Dermatoli ana 1,0 Lanolini Vaselini ana 5,0 M.D.S.: Apply to the affected skin. Specify the type of the disperse system:

Suspension ointment

Combined ointment

Extraction ointment

Solution ointment

Hydrophilic ointment

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Which of the following antibiotics can be identified by means of the maltol test?

Amoxicillin

Streptomycin sulfate

Lincomycin hydrochloride

Kanamycin monosulfate

Doxycycline hydrochloride

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Pharmacies as legal entities must have statutory capital in order to get registered with state authorities. Specify the amount which is identified as the statutory capital:

Total assets

Amount recorded in the constituent documents

Amount of noncurrent assets

Total sources of funds

Outstanding amount

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A pharmaceutist prepared 100,0 g of oil emulsion using 5% solution of methyl cellulose as an emulsifier. Specify the required amount of oil and emulsifier for the drug preparation:

10,0 g, 30,0 g

20,0 g, 30,0 g

10,0 g, 10,0 g

10,0 g, 20,0 g

20,0 g,10,0g

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A pharmaceutist prepared the 2% aqueous solution by dissolving the drug substance triturated in a mortar. What substance is this technology typical for?

Boric acid

Potassium bromide

Potassium permanganate

Osarsolum

Calcium gluconate

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A pharmaceutist prepares powders with papaverine hydrochloride. What hand scales should be used for weighing out 0,05 g of substance?

BP 20,0

BP 2,0

BP 10,0

BP 5,0

BP 1,0

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What drug can be recommended for symptomatic treatment of muscle pain in a 5-year-old child?

Diclofenac sodium

Paracetamol

Acetylsalicylic acid

Indomethacin

Celecoxib

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A pharmacy received a prescription for an oil liniment including streptocidum. What is the type of disperse system of this preparation?

Alloy

Combined

Suspension

Solution

Emulsion

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White precipitate produced by the reaction of morphine hydrochloride with ammonia solution dissolves in sodium hydroxide solution due to the presence of the following group in the structure of morphine hydrochloride:

Alcoholic hydroxyl

Aldehyde group

Keto group

Phenolic hydroxyl

Carboxyl group

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A person got poisoned with alcohols. What alcohol derivatives are used for the analysis by gasliquid chromatography?

Alkyl sulfites

Alkyl nitrates

Alkyl sulfates

Alkyl nitrites

Alkyl acetates

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A pharmaceutical analyst identifies the substance of potassium acetate. What reagent confirms the presence of potassium cation in the substance?

Sodium hydroxide

Zinc oxide

Potassium permanganate

Iron (III) chloride

Tartaric acid

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According to SPhU, formaldehyde can be identified when a sample is reacted with chromotropic acid solution in the presence of concentrated sulfuric acid. What colour is formed by this reaction?

Brown

Blue

Yellow

Violet

Green

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Stimulation of beta-cells of the pancreas causes the hypoglycemic effect of the following drug:

Heparin

Glibenclamide

Retabolilum

Prednisolone

Adrenaline hydrochloride

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A patient with Parkinson’s disease has been prescribed a drug with a predominant effect on the dopaminergic system. What drug is it?

Zopiclone

Droperidol

Lorazepam

Aminazine

Levodopa

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Exacerbation of urolithiasis has caused a renal colic in the patient. What drug must be administered to arrest the colic?

Drotaverine hydrochloride

Siliborum

Neostigmine methylsulfate

Aethimizolum

Almagel

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A patient with atopic dermatitis presented to the hospital. Which drug with anti-inflammatory and antiallergic effect should be administered to this patient?

Aethamidum

Retabolilum

Prednisolone

Oxytocin

Insulin

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What solution is used for the detection of iron (II) ions under the SPhU requirements?

Sodium hydroxide

Silver nitrate

Potassium ferricyanide

Lanthanum nitrate

Ammonia

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The manufacturing pharmaceutical company Elema set up its own corporate pharmacy. In this case, it uses the following distribution channel:

Fourth level

Zero level

Third level

First level

Second level

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An analytical laboratory has the task to confirm the presence of ethylenedi-amine in the aminophylline. Which of the following reagents alows to detect ethylenediamine?

Sodium hydroxide

Barium chloride

Silver nitrate

Copper (II) sulfate

Concentrated sulfuric acid

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Help the doctor to select a drug from the group of non-steroidal antiinflammatory drugs, which is an inhibitor of COX-2 and does not damage the stomach:

Celecoxib

Indomethacin

Diclofenac sodium

Acetylsalicylic acid

Paracetamol

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A patient with acute intoxication has been administered a loop diuretic in order to cause the forced diuresis. What drug is it?

Hydrochlorothiazide

Triamterene

Spironolactone

Mannitol

Furosemide

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A hypertensive patient has been administered lisinopril. What side effect is typical for this drug?

Vomiting

Constipation

Dry cough

Insomnia

Increased appetite

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Advise an internship doctor on why iron preparations should not be administered along with antacids:

This causes increased binding to blood proteins

This causes malabsorption of iron

This accelerates elimination of iron preparations

This impairs deposition of iron in the body

This increases intoxication with iron preparations

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Pharmaceutical analyst working at the laboratory of the State Inspectorate for Quality Control of Medicines identifies the drug substance 'Glucose anhydrous'with copper-tartrate solution ( Fehling’s reagent). What colour precipitate is produced?

Black

Red

Blue

Purple

White

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Senior nurse of the surgical department of the city hospital applied to the interhospital pharmacy. Specify the supporting document for the dispension of dressing material from this pharmacy:

Passport

Invoice

Requisition

Certificate

Tax invoice

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Under the SPh of Ukraine, one of the reactions for the detection of calcium cation presence in drugs is the reaction with:

Alizarin

Glyoxal-hydroxyanil

Sulfuric acid

Hydroxyquinoline

Hydroxylamine

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A pharmaceutical analyst working at the laboratory of the State Inspectorate for Quality Control of Medicines identifies 'Thiamine hydrobromide'with the solution of potassium ferricyanide in the alkaline medium. When doing this, he observes a light-blue fluorescence of the alcohol layer in UV light. What product is thus formed?

Murexide

Ninhydrin

Quinoneimine

Thalleioquin

Thiochrome

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Treatment of a patient who has developed an attack of bronchial asthma for the first time should be started with:

M-anticholinergic drugs

Inhalation of ^-agonists

Яг-histamine blockers

Inhalation of glucocorticosteroid

Agonists parenterally

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A patient with acute heart failure and cardiac glycoside intolerance was given an injection of dobutamine. What is the mechanism of its action?

Blockade of K+-, Na+-ATPase

Stimulation of M-cholinergic receptors

Stimulation of ^-adrenoceptors

Inhibition of phosphodiesterase

Stimulation of a 1 -adrenoceptors

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Specify the indicator which measures the total contribution of various solutes to the osmotic pressure of the solution:

Isotonicity

Isoviscosity

Osmolality

Apyrogenicity

Isohydricity

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When setting up a joint-stock company the founders discussed the issues of financial liability. What is the liability of the board members in a joint-stock company?

Limited to the amount of deposits

Limited to the contributions to the statutory fund and their property

Limited to the value of their shares

Unlimited and solidary

Limited to the double amount of deposits

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A pharmacy opens a bank account to store funds and conduct ongoing business transactions. What kind of account should be opened?

Letter of credit

Investment

Provisional

Deposit

Current

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A female patient has a sleep disorder after stress. Which of the following hypnotic drugs should be preferred for the treatment of insomnia?

Nitrozepam

Barbital

Chloral hydrate

Phenobarbital

Aminazine

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Precipitation reactions are used to establish the identity of drugs. Cation of sodium in sodium citrate can be identified by the formation of a white precipitate with:

Iron (III) chloride

Silver nitrate

Barium chloride

Potassium permanganate

Potassium ferrocyanide

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A pharmaceutical analyst analyzes xeroform. Which of the following reagents can he use to identify bismuth in xeroform?

Barium chloride

Ammonium hydroxide

Sodium sulfide

Copper sulphate

Potassium sodium tartrate

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It is required to perform the extraction of medical poisons isolated from the biological material by the method of VP Kramarenko. At the same time, what substance will be extracted from the acidic medium?

Aminazine

Benzonal

Codeine

Papaverine

Ephedrine

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A forensic medicine laboratory received some biological material. It should be tested for the presence of trichlorfon and dichlorvos. For their isolation a toxicologist infuses them with:

Water alkalized with ammonia solution

Chloroform

Propanol acidified with oxalic acid

Water acidified with sulfuric acid

Ethanol acidified with oxalic acid

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Pharmacies prepare injectable solutions. Which solution is prepared without any stabilizer?

Glucose solution

Sodium bicarbonate solution

Solution of caffeine sodium benzoate

Sodium thiosulfate solution

Novocaine solution

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A pharmacy sells medicines. Which of the following medicines is on the list of the controlled substances?

Tramadol

Postinor

Hydrocortisone acetate

Streptocid

Gentamicin sulfate

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A pharmaceutist has to prepare an aqueous extract of medicinal plants. What can be used as a substitute of plant material in the drug preparation?

Standardized extract concentrate

Thick extract

Tincture

Liquid extract

Aromatic water

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A 65-year-old female patient with a fracture of mandible has been prescribed a drug from the group of narcotic analgesics. Specify this drug:

Heparin

Piracetam

Furosemide

Cinnarizine

Promedol

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A hypertensive patient has been prescribed a drug from the group of nonselective betablockers. Specify this drug:

Anapriline

Labetalol

Adrenaline hydrochloride

Prazosin

Neostigmine methylsulfate

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A patient has a history of cholelithiasis. What drug should be administered to prevent biliary colic?

Almagel

Contrycal

Pancreatin

Bisacodyl

Magnesium sulfate

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From the pharmaceutical stock select a reversible anticholinesterase drug to be administered to the patients with atony of the intestine and urinary bladder in the postoperative period:

Atropine sulfate

Proserin

Phosphacolum

Dithylinum

Benzohexonium

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A patient after acute myocardial infarction has been recommended to take acetylsalicylic acid for 3-4 months. What effect of acetylsalicylic acid would be most relevant for this patient?

Antiinflammatory

Analgesic

Antipyretic

Spasmolytic

Antiplatelet

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Rose essential oil is used as an antiinflammatory and antispasmodic agent. It is localized in the following excretory structures:

Essential oil glandules

Essential oil conceptacles

Secretory cells

Glandular spots

Glandular hairs

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Production, labour and socioeconomic relations between the head of a pharmaceutical company and the workforce are regulated by:

Collective agreement

Corporate code

Labour contract

Contract

Statute

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A pharmacy makes bulk purchases of health and hygiene products. The agent works under a contract with the manufacturer and operates on his account. The agent may be given the exclusive right to sell goods in certain regions. Specify this agent:

Consignee

Commission agent

Dealer

Broker

Wholesale agent

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A pharmaceutical company has made a decision to expand its activities. The process of the company’s activity expansion by penetration into new fields of the branch is called:

Diversification

Segmentation

Centralization

Integration

Conglomeration

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A pharmacy prepares ointments with extracts. What is the way to incorporate the dry and thick extracts into the ointments?

To dissolve them in water first

To disperse them with a liquid which is compatible with the base

To disperse them with ethanol

To triturate them first with alcohol-water-glycerol [1:6:3] mixture

To incorporate them directly into the molten ointment base

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A pharmacy received a prescription: Rp.: Dibazoli0,05 Papaverini hydrochloridi 0,15 Sacchari 2,5 M. fiat pulv. Divide in partes aequales №10. Specify the weight of a single powder dose :

0, 30

0, 25

2, 7

0, 26

0,27

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A pharmaceutist working at an analytical laboratory is engaged into sulfite-ion identification of a drug in compliance with the requirements of SPhU. What reagent becomes colourless in this study?

Potassium nitrate solution

Potassium iodide solution

Iodine solution

Ammonia solution

Iron (III) chloride solution

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Select a drug for the treatment of bronchial asthma from the group of fi2-agonists:

Ketotifen

Atrovent

Aminophylline

Salbutamol

Beclomethasone

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Ampules are produced of glass with appropriate heat resistance. An ampule would meet the requirements of technical standards if the ampule glass has the following characteristic:

Withstanding the stresses during production and transportation

Quality ampule sealing

Protection of light-sensitive materials

Thermal shock resistance

Easy cutting of capillaries

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Ampule quality control involves testing for chemical resistance. What methods are used to test this indicator?

Autoclaving followed by titration with a solution of hydrochloric acid

Various acid-base indicators, pH meter, gravimetric methods

Photoelastic method

Visual, gravimetric methods

Exposing the glass samples to the action of sodium carbonate and sodium hydrocarbonate solutions

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A pharmaceutist prepared the massage cream of the following composition: Beeswax 12,0 Almond oil 68,5 Spermaceti 12,0 Anhydrous lanolin 7,5 Essential oil of lavender 3 drops. Specify the cream type:

Emulsion

Suspension

Non-oily

Oily

Combined

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What is the function of anhydrous lanolin in the suppository mass used for suppositories prepared by hand rolling?

Solvent

Emollient

Preservative

Solubilizer

Plasticizer

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Plantain leaves are used for production of Plantaglucidum which has antiulcerogenic action. The plant material analysis involves quantitative determination of the following class of compounds:

Terpenes

Amarines

Vitamins

Polysaccharides

Carotenoids

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What herbal drug produced form alkaloid-containing raw materials can be recommended for neurasthenia, insomnia, menopausal disorders?

Glaucine hydrochloride

Vinblastine

Securinine nitrate

Ergotamine

Novopassit

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A pharmaceutist has prepared a suspension with a hydrophobic substance. What stabilizer is required for its preparation?

Sodium thiosulfate

Sodium chloride

Polyethylene oxide

Glucose

5% solution of methyl cellulose

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A patient has been found to have pesticide intoxication. Biochemical (cholinesterase) test was positive. What pesticide is likely to have caused the intoxication?

DDT

Heptachlor

Dichlorvos

Hexachlorocyclohexane

Ethyl mercury chloride

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Which of the following sublingual drugs quickly relieves an attack of stenocardia?

Nitroglycerine

Digoxin

Corglycon

Lisinopril

Amiodarone

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Diazepam is used for the treatment of neuroses due to the following pharmacological effect:

Anxiolytic

Antipyretic

Antidepressant

Diuretic

Analgesic

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A patient has been administered a spasmolytic from the group of muscarinic receptor antagonists as a part of the complex treatment for renal colic. Specify this drug:

Neostigmine

Benzohexonium

Atropine

Galantamine

Dithylinum

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One of the recent industrial medical forms that is used in pediatric practice and intended for young children unable of swallowing tablets is:

Gelatin microcapsules

Dragee

Granules

Spansules

Tubatines

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What final document is used for the preparation of the report on the discrepancies revealed in course of the inventory at the pharmacy?

Inventory item description

Commercial report

Invoice

Checklist

Act on the inventory results

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Pharmaceutical market of Ukraine comprises pharmacies of various forms of ownership. Specify the form of ownership for a community pharmacy:

Group of shareholders

Private person

Workforce of an enterprise

-

Territorial community

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A patient with a history of allergic rhinitis has been prescribed ephedrine in form of nasal drops. The patient has significantly benefited from nasal instillation, and this stimulated him to use the drug every two hours. But under these conditions the drug appeared to be ineffective. What is the most likely cause of this phenomenon?

Tachyphylaxis

Drug dependence

Allergy

Cumulation

Idiosyncrasy

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A pharmaceutic plant producing aerosol forms uses liquefied gases as propellents. Which of the following substances relates to the group of liquefied gases?

Freons

Nitrous oxide

Ethylene chloride

Methylene chloride

Nitrogen

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A pharmaceutist has to prepare a drug by the prescription: Rp.: Natrii hydrocarbonatis 2,0 Natrii benzoatis 1,5 Liquoris Ammonii anisatis 4 ml Aquae Mentae 100 ml M.D.S. 1 tablespoon 3 times a day. Specify the component that is added in the first place :

Liquoris Ammonii anisatis

Mint water

Sugar syrup

Sodium benzoate

Sodium hydrogen carbonate

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A person got poisoned with an unknown substance. Chemico-toxicological test for the isolated toxin with Dragendorff’s, Sonnenschein’s, Schei-bler’s reagents caused setting of sediments. The specific study should be focused on the following group of toxic substances:

Ammonia and its salts

Methyl alcohol

Alkaloids and nitrogen-containing compounds

Hydrocyanic acid

Metal toxins

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A laboratory for drug quality control checks the quality of the drug substance nitrofural ( furacilin). The chemical denomination of this drug is :

5-Nitro-2-furaldehyde semicarbazone

1,2-Diphenyl-4-butylpyrazolidine-dione-3, 5

1-(5- Nitrofurfurilidenamino)imidazolidine-2,4-dione

N(-(2-Furantdil)-5-fluorouracil

7- Nitro-5-phenyl-1,3-dihydro-2H-1,4-benzodiazepin-2-one

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A 25-year-old patient with frequent migraine attacks has been prescribed sumatriptan. Specify the mechanism of its action:

Selective antagonist of 5 — HTX-serotonin receptors

Selective «-blocker

Stimulator of в-adrenergic receptors

Nonselective «-blocker

Selective agonist of 5 — HTi-serotonin receptors

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A 43-year-old patient with a severe form of rheumatoid arthritis has been administered a certain drug for background therapy. Specify this drug:

Nimesulide

Methotrexate

Methylprednisolone

Diclofenac sodium

Prednisolone

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In order to analyze marketing opportunities and make a forecast of the market position a pharmaceutical company can use a matrix allowing the company to find new markets ( geographical) or identify new areas of using traditional medicines. What matrix is used by a pharmaceutical company to identify its market position?

Porter’s matrix

Ansoff matrix

Competitive force models

Boston Consulting Group matrix

Matrix of competitive advantages

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A female 49-year-old patient complains of compressing headache in the occipital region, dizziness, increased AP. The patient has a history of diabetes melli-tus type II. What diuretic DOES NOT affect the blood glucose level?

Ethacrynic acid

Urea

Furosemide

Indapamide

Hypothiazide

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A 65-year-old patient complains of nausea, vomiting, lethargy, seeing yellow spots in front of his eyes. The patient daily takes 0,25 mg of digoxin, 100 mg of aspecardum, 50 mg of metoprolol. What pathological condition is this syndrome typical for?

Food poisoning

Hypersensitivity reaction

Withdrawal syndrome

Glycoside intoxication

Tachyphylaxis

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Pharmaceutical plants produce ointments on various bases. Specify the ointment base having the most pronounced osmotic properties:

Vaseline, lanolin

Polyethylene oxide

Hydrogenated fat

Methyl cellulose

Silicon

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Ampule workshop of a pharmaceutical factory produces the procaine hydrochloride solution. This solution is stabilized by adding:

0,1 mol/l of sodium hydrogen carbonate solution

0,1 mol/l of sodium hydroxide solution

0,1 mol/l of hydrochloric acid solution

1,5 g of amino-propylene glycol

20,0 of sodium hydrogen carbonate

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Some alkaline solution was added to the alcohol solution of ftivazide, causing the solution to change colour from the light yellow to the orange-yellow. Subsequent addition of hydrochloric acid made the solution become again light yellow, and then orange-yellow. What properties of ftivazide are proved by this reaction?

Reducing

Amphoteric

Base

Oxidative

Acid

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When atropine sulfate is tested for purity, the alkaloids and degradation products are detected by TLC. For this purpose the chromatographic plate is sprayed with a solution of:

Tetrabutylammonium hydroxide

Acetic-hydrochloric dini- trophenylhydrazine

Ninhydrin

Potassium iodobismuthate

Ammonia

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Specific impurity of thiosulfates in Natrii iodidum and Kalii iodidum is identified by adding starch and iodine solutions. The absence of impurities is proved by:

Yellow colour

Blue colour

White precipitate

Disappearance of the blue colour

Discolouration of the solution

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Bronchodilatory effect of shortacting ^2-adrenoceptor agonist salbutamol develops after:

4-6 hours

20-30 minutes

45-60 minutes

5-10 minutes

2-3 hours

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A12 weeks pregnant patient has been hospitalized with symptoms of acute cystitis. What antibiotic can be recommend in this case?

Metronidazole

Ciprofloxacin

Amoxicillin

Tetracycline

Gentamicin

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Issuing prescriptions and orders for drugs and medical products is regulated by the Order № 360 dated 19.07.2005 (as amended). Specify the prescription form for phenobarbital as a part of a combined dosage form:

F-1

Prescription forms F-1 and F-3 in duplicate

F-2

F-3 in duplicate

No prescription

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Vacation leaves for employees of pharmacies include paid annual, additional, sabbatical, social leaves, as well as unpaid leaves. What is the total duration of the paid basic and additional vacation leave?

65 calendar days

60 calendar days

59 calendar days

70 calendar days

90 calendar days

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Representatives of the family Solanaceae are widely used in medical practice as alkaloidcontaining plants. Which representative is the source for production of semi-synthetic steroid hormones?

Solanum laciniatum

Datura Stramonium

Solanum tuberosum

Hyoscyamus niger

Atropa belladonna

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After harvesting the calamus rhizomes the received material should be dried. What temperature range is required for obtaining good-quality raw material?

70-80 °C

60-70 °C

80-90 °C

40-60 °C

35-40°C

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A pharmaceutist has to prepare 10% alcohol solution of iodine. What is the required concentration of ethanol for this purpose?

60 %

96 %

95%

70 %

40 %

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Field horsetail grass is recommend as a diuretic. What herbal material can be used as a substitute?

Herba Aervae lanatae

Herba Leonuri

Herba Adonidis

Herba Convallariae

Herba Menthae piperitae

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A pharmaceutist prepares an infusion at a ratio of 1:30. What plant material would be used?

Marshmallow root

Oak bark

Sage leaves

Shoots of Marsh Labrador tea

Lily of the valley grass

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Under the SPhU (appendix 2), leaves of ginkgo are standardized by the content of:

Saponins

Chromones

Coumarins

Flavonoids

Alkaloids

‹ Назад

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The pharmaceutical market is characterized by the seasonal fluctuations in demand for anticold medicines. What kind of marketing is used in case of such demand?

Remarketing

Counteractive

Developing marketing

Synchromarketing

Conversive

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Economic analysis of pharmacy activity involves a number of absolute indices. What index is determined by the formula: 'income from sales - prime cost of goods':

Amount of costs

Level of costs

Net profit

Gross profit

Total balance

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Salicylic acid and its derivatives may be the cause of acute intoxication. When salicylates are analyzed by TLC method, the chromatographic plate is sprayed with:

Forrest reagent

Dragendorff’s reagent

Marquis reagent

Solution of mercury (II) sulfate and chloroform solution

Solution of iron (III) chloride

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The simple sugar syrup consists of:

65 parts of sugar, 33 parts of water, 2 parts of 90% alcohol

64 parts of sugar and 36 parts of water

73 parts of sugar, 22 parts of water, 5 parts of 90% alcohol

45 parts of sugar and 55 parts of water

50 parts of sugar and 50 parts of water

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Prescriptions for the controlled drugs dispensed under the reimbursement program (except for the narcotic and psychotropic preparations in substance) are issued on the following prescription form:

№3, single copy

№3 in duplicate

№1 in duplicate

№1, single copy

№1 and № 3

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Quarterly evaluation of business and financial performance of a pharmacy involves calculating its profitability. For this purpose the following data is used: turnover - 100 thousands UAH, gross profit - 25 thousands UAH, expenditures -1 thousand UAH. Calculate the profitability of the pharmacy:

15%

25 %

22 %

10 %

20 %

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A patient suffering from epilepsy has taken phenobarbital for a long time and developed drug tolerance. What is the mechanism of this phenomenon development?

Accumulation of substances in the body

Acceleration of biotransformation

Inhibition of biotransformation

Absorption process reduction

Receptor’s sensitivity enhancement

‹ Назад

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Who is responsible for the acceptance of goods and medical products with accompanying incoming quality control?

Pharmaceutist

Analyst

Supplier pharmaceutist

Head of pharmacy

Authorized representative

‹ Назад

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During steam distillation of voltile poisons the first portion of the distillate is collected in a receiver with 2% solution of sodium hydroxide. It is used to detect:

Formaldehyde

Phenol

Cyanides

Acetates

Ethanol

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Alkaloid glaucine has an antitussive effect that is stronger and longer if compared to that of codeine, and exhibits no narcotic side effects. What drug plant contains glaucine?

Celandine

Henbane bell (Scopolia carniolica)

Yellow hornpoppy

Thermopsis lanceolata

Datura

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A pharmacy has no quinquelobate motherwort in stock. It can be substituted by the following herbal material:

Raspberry fruits

Linden flowers

Beggarticks grass

Rhizomes and roots of valerian

Hypericum grass

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Drug plant Dioscorea nipponica is the source for production of Polysponi-num drug which is used in the complex treatment of atherosclerosis. Specify the active compounds of dioscorea material:

Steroidal saponins

Triterpene saponins

Cardiac glycosides

Alkaloids

Essential oil

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A drug raw material from the family Polygonaceae had been sent to a laboratory for analysis. On macroscopic examination the material was identified as a herbaceous plant with lanceolate leaves with a red spot, and filmy ocreae covered with appressed hairs. The plant had the apical inflorescence in dense spicate panicles. What plant is it?

Redshank (persicaria)

Snakeweed

Common buckwheat

Biting knotweed

Common knotweed

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A 35-year-old patient with tachycardia has been administered propranolol. Which of the following reactions may be caused by the use of beta-blockers?

Drug dependence

Bronchospasm

Constipations

Blood pressure rise

Cumulation

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Under the SPhU requirements mercury salts are indentified by means of interaction with sodium hydroxide solution. Specify the colour of the precipitate that is produced as a resut of this reaction:

Blue

Red

Yellow-green

White

Yellow

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A 17-year-old patient complains of persistent thirst, dry mouth, frequent urination, increased appetite. Blood glucose is at the rate of 11 mmol/l. The patient has been diagnosed with diabetes melli-tus type I. What drug is indicated for treatment?

Asparcamum

Maninil

Glibenclamide

Insulin

Acarbose

‹ Назад

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A pharmacy serves the polyclinics of a city district. Specify the bill of materials that shows the number of drugs dispensed on prescriptions of the doctors who work in the polyclinics:

Medical

Inpatient

Polyclinic

Outpatient

-

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At the end of the reporting period a pharmacy makes an analysis of its commercial and financial activities. What economic index describing the commercial and financial performance is defined as the ratio of the pharmacy profit to the turnover?

Distribution costs

Bill of material

Retail turnover

Wholesale turnover

Profitability

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Phytochemical workshop of a factory manufactures pancreatin. What is the source material for obtaining pancreatin?

Heart of cattle

Gastric mucosa of pigs

Egg white

Pancreas of pigs or cattle

Lungs of cattle

‹ Назад

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Which of the following diuretics SHOULD NOT be administered to patients with impaired hearing?

Chlorthalidone

Spironolactone

Clopamide

Indapamide

Furosemide

‹ Назад

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A patient who has been taking acetylsalicylic acid developed hemorrhages of mucous membranes. This phenomenon is associated with:

Changed volume of distribution

Inhibition of the prothrombin synthesis

Increased absorption in the gastrointestinal tract

Decreased absorption in the gastrointestinal tract

Disorder of protein binding

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Simultaneous use of paracetamol and acetylcysteine causes:

Inhibition of paracetamol absorption

Increase of mucolytic action of acetylcysteine

Reduction of anti-inflammatory action of paracetamol

Reduction of paracetamol hepatotoxi-city

Increase of paracetamol nephrotoxicity

‹ Назад

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Simultaneous use of gentamicin and acyclovir tablets increases the risk of:

Neurotoxicity

Cardiotoxicity

Likelihood of allergic reactions

Hepatotoxicity

Nephrotoxicity

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Simultaneous use of doxycycline hydrochloride and oral contraceptive causes:

Increase of the antibacterial effect of doxycycline

Reduction of the antibacterial effect of doxycycline

-

Increase of oral contraceptives effectiveness

Reduction of oral contraceptives effectiveness

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In case of simultaneous use of metronidazole and oral anticoagulants derived from coumarin patients must be warned about:

Higher neurotoxicity

Reduction of anticoagulants effect

Potentiation of anticoagulants effect and the risk of bleeding

Reduction of metronidazole effect

Potentiation of metronidazole effect

‹ Назад

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Business transactions of pharmacies are reported in the accounts. Specify the account that reports the settlements with debtors and creditors:

Business

Negative

Positive

Trial balance

Nominal

‹ Назад

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Apart from goods sales, there are other business transactions that can be characterized as goods disposal. Which of the following business transactions reduces the stock at pharmacies?

Revaluation for the packing and laboratory work

Bringing the oversupply on charge

Reclassifying other supplies as goods

Bringing the glassware on charge

Disposal of products for economic needs

‹ Назад

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A pharmaceutical analyst analyzes the substance of ascorbic acid in compliance with the requirements of the State Pharmacopoeia of Ukraine. To identify the oxalic acid impurities he uses the solution of:

Sodium hydrocarbonate

Sodium thiosulfate

Calcium chloride

Sodium sulfate

Sodium chloride

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Phenobarbital drug has a sedative, hypnotic and anti-epileptic effect. What is its international nonproprietary name?

Salol

Diazepam

Chloramphenicol

Nitrofurazone

Luminal

‹ Назад

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A 70-year-old patient with stenocardia claims that the pharmacy sold him a drug that relieved an attack of stenocardia but instead caused an acute bursting headache. What antihypertensive drug is this side effect typical for?

Amlodipine

Trimetazidine

Metoprolol

Nifedipine

Nitrosorbid

‹ Назад

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During the working day a pharmaceutist prepared five dosage forms. Which of them requires a complete chemical control?

Ear drops with levomycitin

5 % aethonium solution

Eye drops 10 ml of 2% ethylmorphine hydrochloride solution

Mixtura Pavlovi

Antipruritic ointment

‹ Назад

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Commercial and financial activity of a pharmacy involves using returnable tare. Which of the following containers are returned to the supplier?

Glass-stoppered bottles

Packaging materials

Glassware

Paper boxes

Metal cylinders

‹ Назад

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A pharmacy plans to expand the production of medicines. For this purpose it purchased the production equipment at a cost of 7000 uAh. The cost of the equipment will be recorded to the balance of the pharmacy as:

Revalued amount

Fair value

Residual

Amortization cost

Initial cost

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An accountant of a pharmacy issued a cash receipt voucher for the sales proceeds. What document is used to register cash receipt and cash payment vouchers before the cash arrives to the cashiers?

Cash report

Cash book

Register of receipt and payment cash documents

Pay list

Ledger of cash dispensed and received by the senior teller

‹ Назад

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Biochemical blood test revealed low level of serum iron. What disease are these changes typical for?

Bronchial asthma

Bronchiectasis

Acute bronchitis

Iron-deficiency anemia

Pneumonia

‹ Назад

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A patient who has been treated for hypertension complains of cough. Objective examination reveals no changes in the lungs. Which of the following drugs might have caused cough?

Amlodipine

Hypothiazide

Clonidine

Captopril

Nebivolol

‹ Назад

Далі ›

What non-narcotic antitussive drug of central action can be used for dry cough?

Glaucine

Ambroxol

Mucaltin

Acetylcysteine

Codeine

‹ Назад

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Galenic preparations are produced by using various extractants. What extractants require pressure as a prior condition for the extraction process?

Dichloroethane, chloroform

Ethanol

Methyl alcohol, acetone

Vegetable oils

Liquefied gases

‹ Назад

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Menthol has anesthetic and antiseptic effect. What plant is the source of menthol?

Folia Absinthii

Folia Menthae piperitae

Folia Salviae

Folia Eucalypti

Folia Uvae ursi

‹ Назад

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Hydrocyanic acid and its salts are extremely toxic substances. In humans, they are partly neutralized by enzymatic conversion into:

Thiocyanate

Ethanol

Carbon (IV) oxide

Acetic acid

Nitrogen (II) oxide

‹ Назад

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Methyl alcohol which is widely used in industry causes severe health disorders when enters the human body even in small amounts. This effect is induced by the action of the following major metabolites of methanol:

Formaldehyde and formate acid

Ethyl alcohol and ethyl acetate

Ethanol and acetaldehyde

Acetic acid and acetaldehyde

Methyl acetate and ethyl acetate

‹ Назад

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Enrolled in private pharmacies to implement a drug whose active ingredient is the chemical name of 2-chloro-10-(3’-dimethylaminopropyl)-phenothiazine hydrochloride. Specify this drug:

Chlorpromazine hydrochloride

Trifluoperazine hydrochloride

Diphenhydramine hydrochloride

Promethazine hydrochloride

Clonidine hydrochloride

‹ Назад

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The thyme grass is used for the production of herbal medical products for the treatment of respiratory tract infections. Under the SPhU, the herbal raw material is subject to chromatographic identification by means of thin layer chromatography. What substances are detected on the chromatographic plate after its treatment with due reagent?

Arbutin and methyl arbutin

Thymol and carvacrol

Apigenin and luteolin

Quercetin and rutin

Atropine and hyoscyamine

‹ Назад

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Flower buds of clove contain the essential oil used for production of herbal antiseptics. Under the State Pharmacopoeia of Ukraine, the raw materials are identified by the method of thin layer chromatography. What zones can be identified on the chromatographic plate after their treatment with reagent?

Eugenol and caryophyllene

Hyoscyamine and scopolamine

Scopoletin and umbeliferon

Apigenin and luteolin

Quercetin and rutin

‹ Назад

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Specify the base for the preparation of antibiotic ointments:

5 parts of vaseline + 1 part of lanolin

7 parts of vaseline + 3 part of lanolin

5 parts of vaseline + 5 part of lanolin

8 parts of vaseline + 2 part of lanolin

6 parts of vaseline + 4 part of lanolin

‹ Назад

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Business transactions of a pharmacy are recorded in the control accounts as listed in the chart of accounts. The balance on the ledger and sub-ledger accounts is used to fill out the following document:

Profit and loss account

First section of the liabilities side

Assets

Liabilities

Fourth section of the liabilities side

‹ Назад

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A 40-year-old patient has a history of bronchial asthma and heart rhythm disorders in form of bradyarrhythmias. Bronchospasm can be eliminated by the drugs of the following pharmacological group:

в-blockers

Cholinesterase inhibitors

M-cholinomimetics

Muscle relaxants

M-cholinergic antagonists

‹ Назад

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